A few months before I played Last of Us, I read World War Z. It was easy to think the two titles were set in the same universe. Also, it was the first time - but not the last - a video game made me cry.))
For Last of Us, it was the opening scene. The next one that hit me hard was Brothers, specifically, the post-boss fight and ending level. Horizon Zero Dawn got emotional at several points, too, as did Breath of the Wild. Witcher 3 even gave me wet eyes at a few points. However, the game that has emotionally damaged me more than any other is Spider-Man PS4.))
Spider-Man had me rolling on the floor ugly-crying after the conclusion of the main storyline. To make it even worse, I finished it the day after Stan Lee passed away.))