Who was Jacqueline loyal to, before she met Carmen?
Her school friends and her family. They were good people to have around; her life was just rather boring until VILE came along.
Given that Jacqueline is technically someone outside her time, has she had any trouble adjusting to the present?
She's needed quite a bit of help from her VILE colleagues. Luckily for her, they're used to working with people much further outside their times. 45 years or so is a much shorter leap than, say, 400, so while she's needed to get caught up on technological advancements and changes in culture, those are more on the scale of "MP3s instead of 8-tracks" than "indoor plumbing and electricity." She sometimes forgets one cultural shift or another and says something strange as a result, but given that she's a VILE villain, strange is expected, really.